Expression of hMECP2 in Drosophila CNS impairs dendrites and increases kibra.
Mecp2 gain-of-function effects are validated in mouse primary neuron culture.
Mecp2−/Y mice show decreased Kibra levels in cortex, cerebellum, and hippocampus.
Kibra knockdown rescues dendritic defects caused by hMECP2 expression in Drosophila.