Negative regulation of NOD1 mediated angiogenesis by PPARγ-regulated miR-125a

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• 作者：Hyesoo Kang<sup>asup><sup> ; sup><sup>1sup> ; Youngsook Park<sup>asup><sup> ; sup><sup>1sup> ; Aram Lee<sup>asup> ; Hyemin Seo<sup>asup> ; Min Jung Kim<sup>asup> ; Jihea Choi<sup>asup> ; Ha-neul Jo<sup>asup> ; Ha-neul Jeong<sup>asup> ; Jin Gu Cho<sup>asup> ; Woochul Chang<sup>bsup> ; Myeong-Sok Lee<sup>asup> ; Raok Jeon<sup>csup> ; Jongmin Kim<sup>asup><sup> ; sup><sup>jkim@sookmyung.ac.krsup>
• 关键词：Nucleotide-binding oligomerization domain-containing protein 1 ; MicroRNA ; Peroxisome proliferator-activated receptor gamma ; Angiogenesis ; Endothelial cell
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：482
• 期：1
• 页码：28-34
• 全文大小：1440 K
• 卷排序：482

文摘

Expression of NOD1 is regulated by PPARγ signaling in HUVECs. PPARγ-regulated NOD1 expression is mediated at least in part by of miR-125a. NOD1 is a novel target gene of miR-125. miR-125a inhibits inflammation induced angiogenesis in HUVECs. PPARγ activation inhibits inflammation mediated angiogenesis in vitro and in vivo.