Targeting the IL-33/IL-13 Axis for Respiratory Viral Infections

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• 作者：Chantal Donovan¹ ; ² ; Jane E. Bourke¹ ; ² ; Ross Vlahos² ; ³ ; ^{ross.vlahos@rmit.edu.au" class="auth_mail" title="E-mail the corresponding author}
• 关键词：viral infection ; interleukin-33 ; interleukin-13 ; acute exacerbation
• 刊名：Trends in Pharmacological Sciences
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：37
• 期：4
• 页码：252-261
• 全文大小：1536 K

文摘

Lung diseases, such as asthma and chronic obstructive pulmonary disease (COPD), are highly prevalent worldwide. One of the major factors that limits the efficacy of current medication in these patients are viral infections, leading to exacerbations of symptoms and decreased quality of life. Current pharmacological strategies targeting virus-induced lung disease are problematic due to antiviral resistance and the requirement for strain-specific vaccination. Thus, new therapeutic strategies are urgently required. In this Opinion article, we provide state-of-the-art evidence from humans and preclinical animal models implicating the interleukin (IL)-33/IL-13 axis in virus-induced lung disease. Thus, targeting the IL-33/IL-13 axis may be a feasible way to overcome the limitations of current therapy used to treat virus-induced exacerbations of lung disease.