Anakinra induces complete remission of nephrotic syndrome in a patient with familial Mediterranean fever and amyloidosis

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• 作者：Á ; ngel M. Sevillano^a ; ^{sevillano.am@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Eduardo Hernandez^a ; Esther Gonzalez^a ; Isabel Mateo^b ; Eduardo Gutierrez^a ; Enrique Morales^a ; Manuel Praga^a ; ^c
• 关键词：Familial Mediterranean fever ; Amyloidosis ; Colchicine ; Anakinra
• 刊名：Nefrología (English Edition)
• 出版年：2016
• 出版时间：January-February 2016
• 年：2016
• 卷：36
• 期：1
• 页码：63-66
• 全文大小：450 K

文摘

Renal amyloidosis is one of the most severe complications of familial Mediterranean fever (FMF). Colchicine has reduced the incidence of this complication, which now only appears in untreated, under-treated and resistant patients, but it is usually ineffective in patients with advanced amyloidosis. Here we report a patient with FMF and biopsy-proven amyloidosis who presented with nephrotic syndrome despite colchicine treatment. Anakinra (an interleukin-1β inhibitor) was started and a dramatic complete remission of nephrotic syndrome was observed in the following months. Anakinra can be an effective treatment for FMF patients with severe secondary amyloidosis.