Applications and advances of metabolite biosensors for metabolic engineering
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- 作者：Di Liua ; Trent Evansb ; Fuzhong Zhanga ; b ; fzhang@seas.wustl.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：MRTF ; metabolite-responsive transcription factor ; MAGE ; multiplex automated genome engineering ; FAEE ; fatty acid ethyl ester ; ACC ; acetyl-CoA carboxylase ; TCS ; two-component system ; HK ; histidine kinase ; RR ; response regulator ; FPP ; farnesyl pyrophosphate ; FRET ; forster resonance energy transfer ; FPX ; fluorescent protein exchange ; PBP ; periplasmic binding protein ; IPP ; isopentenyl diphosphate ; MCFA ; medium-chain fatty acid
- 刊名：Metabolic Engineering
- 出版年：2015
- 出版时间：September 2015
- 年：2015
- 卷：31
- 期：Complete
- 页码：35-43
- 全文大小：1624 K
文摘
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Genetically-encoded biosensors have been developed to sense various metabolites.
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Metabolite biosensors are engineered with novel sensor–actuator couplings.
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Metabolite biosensors have contributed to improve pathway design and optimization.
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We review recent innovations in creation and application of metabolite biosensors.