Preference for Western diet coadapts in High Runner mice and affects voluntary exercise and spontaneous physical activity in a genotype-dependent manner

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• 作者：Wendy Acosta ; Thomas H. Meek¹ ; Heidi Schutz² ; Elizabeth M. Dlugosz³ ; Theodore Garland Jr. ; ^{tgarland@ucr.edu}
• 关键词：Coadaptaton ; Food choice ; Genotype-by-environment interaction ; Sex differences ; Spontaneous physical activity ; Wheel running
• 刊名：Behavioural Processes
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：135
• 期：Complete
• 页码：56-65
• 全文大小：2569 K
• 卷排序：135

文摘

Preference for Western diet (WD) was tested in genetically High Runner (HR) mice. HR mice of both sexes preferred WD to a significantly greater extent than did Control mice. WD had a larger stimulatory effect on wheel running in HR mice than in Control mice. Home-cage activity declined when wheel running increased (including with WD). Substituting WD for chow revealed strong genotype-by-environment interactions.