Antibiotic Reservoir Injection Reduces Shunt Infection in Adults

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• 作者：Anthony M. Burrows ; Meghan E. Murphy ; David J. Daniels ; Fredric B. Meyer ; ^{Meyer.Fredric@mayo.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Adults ; Antibiotic-impregnated shunt system ; Antibiotic reservoir injection ; Infection ; Ventricular shunts
• 刊名：World Neurosurgery
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：89
• 期：Complete
• 页码：108-111
• 全文大小：535 K

文摘

Shunt infections are a major complication following ventricular shunts in adults that lead to increased heath care costs, patient morbidity, and mortality. Methods to decrease shunt infection include antibiotic-impregnated catheters, protocol-based surgery, and shunt reservoir antibiotic injection.

Methods

An Institutional Review Board–approved retrospective review was performed for all adult shunt surgeries performed from January 2000 to September 2013 at a single academic institution. Records were cross-indexed with hospital billing records to identify patients who received antibiotic injections and cross-referenced with a prospective infection control database of all surgical site infections. The primary outcome measure was shunt infection within 1 year of surgery.

Results

Five-hundred thirteen adult patients met inclusion criteria. Antibiotic reservoir injection was associated with a significantly lower rate of infection (2.6%) when compared with no injection (6.3%, P = 0.0455). The antibiotic injection group also included significantly more patients with infection risk factors than the control group (38.8% vs. 18.0%, P < 0.005).

Conclusion

Antibiotic reservoir injection is an effective method of reducing shunt infections in adults when combined with standard infection control measures.