Intraoperative consultation of central nervous system lesions. Frozen section, cytology or both?

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• 作者：Ali Haidari Sharifabadi^a ; ^{ali.haidari.sharifabadi@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Hayedeh Haeri^a ; ^{haerihay@sina.tums.ac.ir" class="auth_mail" title="E-mail the corresponding author} ; Mehdi Zeinalizadeh^b ; ^{m.zeinalizade@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Neda Zargari^c ; ^{nedazargari62@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Amirnader Emami Razavi^d ; ^{razavinader@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Nargess Shahbazi^a ; ^{shahbaziiiiii@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Malahat Tahvildari^b ; ^{malahatiran@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Farid Azmoudeh-Ardalan^a ; ^{azmoudeh@sina.tums.ac.ir" class="auth_mail" title="E-mail the corresponding author}
• 关键词：CNS ; central nervous system ; GBM ; glioblastoma multiforme ; H&E ; hematoxylin and eosin
• 刊名：Pathology - Research and Practice
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：212
• 期：3
• 页码：179-184
• 全文大小：3591 K

文摘

Frozen section is the traditional method of assessing central nervous system (CNS) lesions intraoperatively. Our aim is to determine the diagnostic accuracy of frozen section and/or cytological evaluation of CNS lesions in our center.

Study design

A total of 157 patients with CNS lesions underwent open surgical biopsy or excision in our center during a period of 2 years (2012–2013). All specimens were studied cytologically; of these specimens, 146 cases were also examined by frozen section. Cytology and frozen section slides were studied separately by two general pathologists who were blind to final diagnoses. The final diagnoses were based on permanent sections and IHC studies.

Results

The accuracy rates of frozen section analysis and cytological evaluation were 87% and 86%, respectively. If the two methods were considered together, the accuracy rate improved to about 95%.

Conclusions

Cytological evaluation is an acceptable alternative to frozen section analysis and also a great supplement to the diagnosis of CNS lesions.