Copper-catalyzed four-component synthesis of imidazo[1,2-a]pyridines via sequential reductive amination, condensation, and cyclization

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• 作者：Emad Allahabadi^a ; Sina Ebrahimi^a ; Mehdi Soheilizad^b ; Mehdi Khoshneviszadeh^c ; Mohammad Mahdavi^a ; ^{Mahdavi_chem@yahoo.com}
• 关键词：Copper-catalyzed ; Imidazo[1 ; 2-a]pyridine ; Reductive amination ; 2-Bromopyridine ; Aldehyde ; Isocyanide ; Sodium azide
• 刊名：Tetrahedron Letters
• 出版年：2017
• 出版时间：11 January 2017
• 年：2017
• 卷：58
• 期：2
• 页码：121-124
• 全文大小：1086 K
• 卷排序：58

文摘

A four component has been used to synthesis imidazo[1,2-a]pyridines. The mechanism relies on sequential reductive amination, condensation, and cyclization. Sodium azide acts as an ammonia surrogate to primary amines in a copper-catalyzed reductive amination of aryl halides.