Creatinine kinase isoenzyme-MB: A simple prognostic biomarker in patients with pulmonary embolism treated with thrombolytic therapy

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• 作者：Mehmet Bozbay ; MD^a ; ^{mbozbay42@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Huseyin Uyarel ; MD^b ; Sahin Avsar ; MD^a ; Ahmet Oz ; MD^a ; Muhammed Keskin ; MD^a ; Veysel Ozan Tanik ; MD^a ; Nijat Bakhshaliyev ; MD^a ; Murat Ugur ; MD^a ; Seckin Pehlivanoglu ; MD^a ; Mehmet Eren ; MD^a
• 关键词：Creatinine kinase&ndash ; MB ; Pulmonary ; Embolism ; Clinical ; Outcomes ; Mortality
• 刊名：Journal of Critical Care
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：30
• 期：6
• 页码：1179-1183
• 全文大小：269 K

文摘

Creatinine kinase isoenzyme–MB (CK-MB) is a biomarker for detecting myocardial injury. The aim of this study was to evaluate the association between admission CK-MB levels and in-hospital and long-term clinical outcomes in pulmonary embolism (PE) patients treated with thrombolytic tissue-plasminogen activator.

Methods

A total of 148 acute PE patients treated with tissue-plasminogen activator enrolled in the study. The study population was divided into 2 tertiles, based on admission CK-MB levels. The high CK-MB group (n = 35) was defined as having a CK-MB level in the third tertile (> 31.5 U/L), and the low group (n = 113) was defined as having a level in the lower 2 tertiles (≤ 31.5 U/L).

Results

High CK-MB group had a higher incidence of in-hospital mortality (37.1% vs 1.7%, P < .001). Admission systolic blood pressure and tricuspid annular plane systolic excursion were lower in the high CK-MB group. In the receiver-operating characteristic curve analysis, a CK-MB value of more than 31.5 U/L yielded a sensitivity of 86.7% and specificity of 83.5% for predicting in-hospital mortality. During long-term follow-up, recurrent PE, major and minor bleeding, and mortality rates were similar in both groups.

Conclusion

Creatinine kinase isoenzyme–MB is a simple, widely available, and useful biomarker for predicting adverse in-hospital clinical outcomes in PE.