Identification of THY1 as a novel thyrotrope marker and THY1 antibody-mediated thyrotrope isolation in the rat anterior pituitary gland
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- 作者：Kotaro Horiguchia ; b ; kota@ks.kyorin-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Takashi Nakakurac ; Saishu Yoshidab ; Takehiro Tsukadad ; Naoko Kannoe ; Rumi Hasegawaa ; Shu Takigamia ; Shunji Ohsakoa ; Takako Katob ; Yukio Katob ; e ; yukato@isc.meiji.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Anterior pituitary gland ; CD90 ; Integrin-β2 ; THY1 ; TSH ; Cell surface glycoprotein
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：11 November 2016
- 年：2016
- 卷：480
- 期：2
- 页码：273-279
- 全文大小：1589 K
文摘
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Thymocyte differentiation antigen 1 (THY1) functions in juxtacrine signaling.
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THY1 and its ligand are expressed in the anterior lobe of the rat pituitary gland.
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THY1 is a novel specific marker of thyrotropes, which produce TSH.
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THY1 antibody-mediated purification yields 83% thyrotrope purity (17-fold enriched).
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The THY1 antibody/pluriBead-cascade cell isolation system is rapid and convenient.