The glucagon like peptide 1 analogue, exendin-4, attenuates oxidative stress-induced retinal cell death in early diabetic rats through promoting Sirt1 and Sirt3 expression
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- 作者：Ying Zenga ; Ke Yangb ; c ; Fang Wanga ; Liping Zhoua ; Yong Hua ; Meiling Tanga ; Shijia Zhanga ; Shuqing Jina ; Jingfa Zhanga ; Juan Wanga ; Weiye Lid ; Lixia Lua ; 1 ; lulixia@tongji.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Guo-Tong Xua ; e ; 1 ; xuguotong@tongji.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Diabetic retinopathy ; Exendin-4 ; Sirtuin ; Oxidative stress ; Cell death
- 刊名：Experimental Eye Research
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：151
- 期：Complete
- 页码：203-211
- 全文大小：1426 K
文摘
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EX4 reduces ROS generation and prevents the cell death in diabetic retinas.
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EX4 improves the visual function of the retinas in diabetic rats.
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The expressions of Sirt1 and Sirt3 are significantly down-regulated in diabetic retinas.
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EX4 up-regulates Sirt1 and Sirt3 expression in retinas of diabetic rats.
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EX4 up-regulates Sirt1 and Sirt3 in H2O2-treated R28 cells.