EX4 reduces ROS generation and prevents the cell death in diabetic retinas.
EX4 improves the visual function of the retinas in diabetic rats.
The expressions of Sirt1 and Sirt3 are significantly down-regulated in diabetic retinas.
EX4 up-regulates Sirt1 and Sirt3 expression in retinas of diabetic rats.
EX4 up-regulates Sirt1 and Sirt3 in H2O2-treated R28 cells.