Acetylshikonin from Zicao exerts antifertility effects at high dose in rats by suppressing the secretion of GTH
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- 作者：Yu He ; Qisen Li ; Meiling Su ; Wendong Huang ; Banghao Zhu ; bhzhu518@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Acetylshikonin ; Toxicity ; Antifertility ; GTH ; Exocytosis
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：5 August 2016
- 年：2016
- 卷：476
- 期：4
- 页码：560-565
- 全文大小：826 K
文摘
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Acetylshikonin from Zicao exerts antifertility effects at high dose in rats.
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The mechanism relies on affecting exocytosis process of gonadotropic hormone.
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Acetylshikonin decreases the expression the critical proteins of exocytosis.
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Acetylshikonin at a dose of under 360 mg/kg does not have antifertility effects.