Effect of zinc and vitamin A supplementation on antibody responses to a pneumococcal conjugate vaccine in HIV-positive injection drug users: A randomized trial

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• 作者：Maria Deloria-Knoll ; Mark Steinhoff ; Richard D. Semba ; Kenrad Nelson ; David Vlahov and Curtis L. Meinert
• 关键词：Vitamin A ; Zinc ; Pneumococcal vaccine ; HIV
• 刊名：Vaccine
• 出版年：2006
• 出版时间：6 March 2006
• 年：2006
• 卷：24
• 期：10
• 页码：1670-1679
• 全文大小：239 K

文摘

HIV-infected individuals have impaired immune responses to vaccines and high rates of pneumococcal disease. The effect of vitamin A and zinc supplementation on the immunogenicity of a 7-valent pneumococcal CRM-197 conjugate vaccine (PC-7) was evaluated in 118 HIV+ injection drug users. Subjects were randomized to oral 400,000 IU vitamin A, 300 mg zinc, vitamin A + zinc, or placebo, then immunized. Geometric mean titer increased 1.3–3.3-fold for all pneumococcal serotypes. PC-7 elicited an immune response in HIV-infected adults but neither vitamin A nor zinc altered the immunogenicity of the evaluated vaccines.