Effect of granulocyte colony-stimulating factor mobilization on the expression patterns, clonality and signal transduction of TRAV and TRBV repertoire

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• 作者：Li Xuan ; Xiuli Wu¹ ; Meiqing Wu ; Yu Zhang ; Hui Liu ; Zhiping Fan ; Jing Sun ; Qifa Liu ; ^{liuqifa628@163.com}
• 关键词：Granulocyte colony-stimulation factor ; TRAV ; TRBV ; CD3 genes ; Graft-versus-host disease
• 刊名：Immunobiology
• 出版年：2012
• 出版时间：August, 2012
• 年：2012
• 卷：217
• 期：8
• 页码：816-822
• 全文大小：1103 K

文摘

The immune modulatory effect of granulocyte colony-stimulating factor (G-CSF) on T cells resulted in an unexpected low incidence of graft-versus-host disease (GVHD) in allogeneic peripheral blood stem cell transplantation (allo-PBSCT). Recently, ¦Á¦Â⁺ T cells are identified as the primary effector cells for GVHD. However, whether G-CSF could influence the repertoire of ¦Á¦Â⁺ T cells (TRAV and TRBV repertoire) and CD3 genes remains unclear. To further characterize this feature, we investigated the effect of G-CSF mobilization on the T cell receptors (TCR) of ¦Á¦Â⁺ T cells (TRAV and TRBV repertoire) and CD3 genes, as well as the association between the changes of TCR repertoire and GVHD in patients undergoing G-CSF mobilized allo-PBSCT. We found that G-CSF mobilization had an effect on the expression patterns, clonality and signal transduction of TRAV and TRBV repertoire. This alteration might play a role in mediating GVHD in G-CSF mobilized allo-PBSCT.