Advances in viral-vector systemic cytokine gene therapy against cancer

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• 作者：Lihua Liu ; Shijie Wang ; Baoen Shan ; Meixiang Sang ; Shuang Liu ; Guiying Wang
• 关键词：Cancer ; Gene therapy ; Cytokine ; Viral-vector
• 刊名：Vaccine
• 出版年：2010
• 出版时间：21 May 2010
• 年：2010
• 卷：28
• 期：23
• 页码：3883-3887
• 全文大小：137 K

文摘

Current strategies for cancer gene therapy consist mainly of direct inhibition of tumor cell growth and activation of systemic host defense mechanisms. Cytokine gene-transduced tumor cells have been used as vaccines in clinical trials, which have shown good safety profiles and some local responses but substantial lack of systemic efficacy. Cytokines should be directed at the level of gene selection and delivery, in order to identify the optimal cytokine and achieve efficient and durable cytokine expression at the level of improving immune stimulation. In this review, we will summarize the current achievements of cytokine gene therapy, especially viral-vector, and their applications in cancer treatment. Additionally, we will also discuss and propose future perspectives about cancer gene therapy.