Molecular cloning, tissue distribution, and pharmacological characterization of melanocortin-4 receptor in spotted scat, Scatophagus argus
详细信息 查看全文
- 作者：Jian-Tao Lia ; b ; 1 ; Zhao Yangc ; 1 ; Hua-Pu Chena ; b ; Chun-Hua Zhua ; b ; Si-Ping Denga ; b ; Guang-Li Lia ; b ; guangli211@163.com" class="auth_mail" title="E-mail the corresponding author ; Ya-Xiong Taoc ; taoyaxi@auburn.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：ACTH ; adrenocorticotropic hormone ; AgRP ; agouti-related protein ; ARC ; arcuate nucleus ; cAMP ; cyclic adenosine monophosphate ; CCK ; cholecystokinin ; CNS ; central nervous system ; GPCR ; G protein-coupled receptor ; MCR ; melanocortin receptor ; MC4R ; melanocortin-4 receptor ; α-MSH ; α-melanocyte stimulating hormone ; NDP-MSH ; [Nle4D-Phe7]-α-melanocyte stimulating hormone ; POMC ; proopiomelanocortin ; SAMC4R ; Scatophagus argus melanocortin-4 receptor ; THIQ ; (N-[(3R)-1 ; 2 ; 3 ; 4-tetrahydroisoquinolinium3-ylcarbo
- 刊名：General and Comparative Endocrinology
- 出版年：2016
- 出版时间：1 May 2016
- 年：2016
- 卷：230-231
- 期：Complete
- 页码：143-152
- 全文大小：1025 K
文摘
- •
Spotted scat MC4R cDNA was cloned and phylogenetic analyses were performed.
- •
Spotted scat mc4r was widely expressed in various peripheral tissues including gonads in sexually divergent pattern.
- •
Spotted scat MC4R had high constitutive activity and bound to THIQ allosterically.