The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW
文摘
Using GPCRdb we found that the binding cavity of GPR139 is 49% similar to MC4R. ACTH, α-MSH and β-MSH activate GPR139 in the low μM-range. We predicted a novel possible cleavage site in POMC leading to the peptide α-MSH1-9. α-MSH1-9 activates GPR139 in the high nM range.