Polymorphisms in schizophrenia candidate gene UFD1L may contribute to cognitive deficits
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- 作者：Vanessa K. Ota ; Arthur A. Berberian ; Ary Gadelha ; Marcos L. Santoro ; Gustavo L. Ottoni ; Camila T. Matsuzaka ; Jair J. Mari ; Maria I. Melaragno ; Diogo R. Lara ; Mar¨ªlia A.C. Smith ; Sintia I. Belangero ; Rodrigo A. Bressan
- 关键词：Executive functions ; Cognition ; Gene
- 刊名：Psychiatry Research
- 出版年：2013
- 出版时间：30 August, 2013
- 年：2013
- 卷：209
- 期：1
- 页码：110-113
- 全文大小：239 K
文摘
We aimed to investigate UFD1L polymorphisms in schizophrenia and in relation to cognition. A total of 299 cases and 363 controls were genotyped, and 130 patients completed nine neuropsychological tests. We found that rs5992403 AA-genotype carriers showed lower scores on the set-shifting task. Therefore, UFD1L may participate in the core cognitive deficits observed in schizophrenia.