Neuroprotective effects of melatonin as evidenced by abrogation of oxaliplatin induced behavioral alterations, mitochondrial dysfunction and neurotoxicity in rat brain
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- 作者：Mohammad Waseem ; Heena Tabassum ; Suhel Parvez ; sparvez@jamiahamdard.ac.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：Mitochondria ; Neurotoxicity ; Oxidative stress ; Melatonin ; Antioxidants
- 刊名：Mitochondrion
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：30
- 期：Complete
- 页码：168-176
- 全文大小：1430 K
文摘
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Neurotoxicity is dose limiting side effects of oxaliplatin, an anticancer agent.
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Melatonin modulated neurological alterations and mitochondrial dysfunction.
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Our data correlate the neuroprotective action of melatonin.
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Melatonin may diminish the neurological complications in oxaliplatin chemotherapy