Protective effect of edaravone against manganese-induced toxicity in cultured rat astrocytes
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- 作者：Vedat Evrena ; Melda Apaydina ; b ; Asghar Khalilnezhada ; Oytun Erbasc ; Dilek Taskirana ; dilek.taskiran@ege.edu.tr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Manganese ; Astrocyte ; Toxicity ; Edaravone ; Oxidative stress
- 刊名：Environmental Toxicology and Pharmacology
- 出版年：2015
- 出版时间：September 2015
- 年：2015
- 卷：40
- 期：2
- 页码：563-567
- 全文大小：942 K
文摘
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Manganese (Mn) may lead to acute and/or chronic toxicity in human and animals.
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Edaravone (EDA) is clinically used for treatment of patients with acute cerebral injury.
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We tested whether EDA has protective effect against Mn toxicity in astrocyte cultures.
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Mn dose-dependently reduced cell viability and increased lipid peroxides in astrocyte cultures.
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Treatment of astrocytes with EDA suppressed oxidative stress and cell death due to Mn exposure.