Antioxidant and antiradical activities of resorcinarene tetranitroxides

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• 作者：Andriy I. Vovk ; Alex ; er M. Shivanyuk ; Roman V. Bugas ; Oxana V. Muzychka ; Andriy K. Melnyk
• 关键词：Antioxidants ; Free radicals ; Resorcinarene ; Nitroxide ; Inhibition
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2009
• 出版时间：1 March 2009
• 年：2009
• 卷：19
• 期：5
• 页码：1314-1317
• 全文大小：370 K

文摘

Resorcinarene oxazines bearing four TEMPO fragments at the wide rim of the macrocycle were prepared through the aminomethylation of resorcinarene octols with 4-amino-TEMPO and formaldehyde. Tetra-TEMPO resorcinarenes are efficient scavengers of 1,1-diphenyl-2-picrylhydrazyl radicals. The model studies revealed that macrocyclic structure and intramolecular hydrogen bonding make considerable contribution to antiradical activity of these compounds. Tetra-TEMPO resorcinarenes show also superoxide dismutase-like activity and efficiently inhibit ABAP-induced peroxidation of linoleic acid.