In vitro effects of the anti-Alzheimer drug memantine on the human erythrocyte membrane and molecular models

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• 作者：Pablo Zambrano^a ; Mario Suwalsky^a ; ^{msuwalsk@udec.cl} ; Fernando Villena^b ; Malgorzata Jemiola-Rzeminska^c ; ^d ; Kazimierz Strzalka^c ; ^d
• 关键词：Memantine ; Human erythrocyte ; Cell membrane ; Phospholipid bilayer
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：29 January 2017
• 年：2017
• 卷：483
• 期：1
• 页码：528-533
• 全文大小：875 K
• 卷排序：483

文摘

The interaction of memantine with human erythrocytes and lipid bilayers were assessed. Memantine induced morphological changes to human erythrocytes. Memantine interacted with classes of phospholipids present in the erythrocyte membrane. Results support the hypothesis that memantine interacts with NMDA receptors.