Oleanane type saponins from the stems of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao

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• 作者：Yi Zhang^a ; ^b ; Xiaoxia Li^a ; Jingya Ruan^a ; Tingting Wang^b ; Yongzhe Dong^a ; Jia Hao^b ; Erwei Liu^a ; ^b ; Lifeng Han^a ; ^b ; Xiumei Gao^a ; ^b ; Tao Wang^a ; ^b ; ^{wangtao@tjutcm.edu.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao ; Stem ; Oleanane type ; Saponin ; HepG2 cells ; Triglyceride accumulation inhibitory effects
• 刊名：Fitoterapia
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：109
• 期：Complete
• 页码：99-105
• 全文大小：972 K

文摘

Astragalus membranaceus is a Traditional Chinese Medicine (TCM) belonging to the Leguminosae family. It has been used as antidiabetic, cardioprotective, and hepatoprotective in the TCM clinic. From the stems of A. membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao, 14 oleanane type saponins (1–14) including eight new ones, astroolesaponins A (1), B (2), C₁ (3), C₂ (4), D (5), E₁ (6), E₂ (7), and F (8) were obtained, and their structures were elucidated by chemical and spectroscopic methods. Compounds 1–5, 7, 8, 11, and 13 showed decreased effects on triglyceride levels in sodium oleate induced HepG2 cells.