Genetic diversity of the Plasmodium falciparum apical membrane antigen I gene in parasite population from the China-Myanmar border area
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- 作者：Xiaotong Zhua ; Zhenjun Zhaob ; Yonghui Fengc ; Peipei Lib ; Fei Liua ; Jun Liua ; Zhaoqing Yangd ; Guiyun Yane ; Qi Fanb ; Yaming Caoa ; ymcao@mail.cmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Liwang Cuia ; f ; luc2@psu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Plasmodium falciparum ; PfAMA1 ; Genetic diversity ; China&ndash ; Myanmar border ; Malaria
- 刊名：Infection, Genetics and Evolution
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：39
- 期：Complete
- 页码：155-162
- 全文大小：820 K
文摘
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The PfAMA1 genetic diversity is higher in Domain I than in other domains.
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10">The PfAMA1 sequence diversity in China–Myanmar border is lower than the other 6 countries.
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15">The entire ectodomain and Domain I of PfAMA1 exposed strong positive selection.
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A continent-wise genetic structure was found among P. falciparum populations.