Giant MACPF/CDC pore forming toxins: A class of their own
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- 作者：Cyril F. Reboula ; b ; James C. Whisstocka ; b ; Michelle A. Dunstonea ; b ; c ;
- 关键词：MACPF ; CDC ; Pore forming toxin ; Perforin ; Membrane Attack Complex ; Pleurotolysin
- 刊名：Biochimica et Biophysica Acta (BBA)-Biomembranes
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：1858
- 期：3
- 页码：475-486
- 全文大小：1243 K
文摘
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The MACPF/CDC family of pore forming toxins (PFTs) form transmembrane pores distinct in size and structure from other PFTs.
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MACPF/CDC PFTs achieve membrane insertion via a common pore forming mechanism.
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Members have also evolved variations of the general mechanism including method of binding to the membrane surface.