The cytotoxic activity of miltefosine against Leishmania and macrophages is associated with dynamic changes in plasma membrane proteins

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• 作者：Kelly Souza Fernandes^a ; ^b ; Paulo Eduardo Narcizo de Souza^c ; Miriam Leandro Dorta^d ; Antonio Alonso^a ; ^{alonso@ufg.br}
• 关键词：Miltefosine ; Leishmania ; Macrophages ; Membrane fluidity ; Protein dynamics
• 刊名：Biochimica et Biophysica Acta (BBA) - Biomembranes
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：1859
• 期：1
• 页码：1-9
• 全文大小：798 K
• 卷排序：1859

文摘

Miltefosine binds to parasite membrane proteins in very large quantities. Two spin labels detected plasma membrane alterations at cytotoxic concentrations. The MT concentration on the membrane was at least 35,000-fold greater than the IC50.