A novel antimicrobial peptide derived from membrane-proximal external region of human immunodeficiency virus type 1
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- 作者：Xiaoqiu Hea ; Huayan Zhanga ; Yuhua Shia ; Xin Gonga ; Shanshan Guana ; He Yina ; Lan Yanga ; Yongjiao Yua ; Ziyu Kuaia ; Dongni Liua ; Rui Huab ; Song Wangc ; Yaming Shana ; d ; shanym@jlu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Antimicrobial peptides ; Antimicrobial activity ; Membrane permeabilization ; Bacterial killing kinetics
- 刊名：Biochimie
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：123
- 期：Complete
- 页码：110-116
- 全文大小：1054 K
文摘
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Novel peptide AP16-A from membrane-proximal external region of HIV-1 is described.
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AP16-A shows antimicrobial activities against Gram-negative and -positive bacteria.
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AP16-A is safe in eukaryocytic cells.
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AP16-A kills Gram-negative bacteria and -positive bacteria by different mechanisms.