Structural and functional characterization of EIAV gp45 fusion peptide proximal region and asparagine-rich layer
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- 作者：Liangwei Duana ; Jiansen Dua ; Xuefeng Wangb ; Jianhua Zhoub ; Xiaojun Wangb ; Xinqi Liua ; liu2008@nankai.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：EIAV gp45 ; HIV-1 gp41 ; Crystal structure ; FPPR ; Asparagine/Glutamine-rich layer ; Membrane fusion ; Conformational transition
- 刊名：Virology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：491
- 期：Complete
- 页码：64-72
- 全文大小：4743 K
文摘
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The crystal structure of EIAV gp45 was determined.
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The fusion peptide proximal region adopts a novel conformation different to HIV-1.
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The asparagine-rich layer includes an extensive hydrogen-bond network.
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These regions of EIAV are highly tolerant to mutations.
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The results provide insight into the mechanism of gp41/gp45-mediated membrane fusion.