A vaccine composed of a hypothetical protein and the eukaryotic initiation factor 5a from Leishmania braziliensis cross-protection against Leishmania amazonensis infection
Two antigenic L. braziliensis proteins were identified. They present high amino acids homology between different Leishmania species. A polyproteins vaccine was based on these two recombinant proteins. Mice were immunized and challenged with L. amazonensis promastigotes. Protection was correlated with low parasite load and a parasite-specific Th1 response.