A CpG ODN was tested as an immunotherapeutic against chronic hepatitis B infection in the woodchuck model.
A P-class CpG ODN was found to stimulate interferon production in vitro and in vivo in chronically infected woodchucks.
Combination treatment with CpG ODN and entecavir led synergistically to effective suppression of WHV load in woodchucks.
CpG ODN activates the innate immune response and contributes to viral suppression in chronically WHV-infected woodchucks.