Simultaneous determination of lovastatin and its metabolite lovastatin acid in rat plasma using UPLC-MS/MS with positive/negative ion-switching electrospray ionization: Application to a pharmacokinetic study of lovastatin nanosuspension
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- 作者：Mengran Guoa ; Longshan Zhaoa ; Mo Lib ; Qiang Fua ; graham_pharm@aliyun.com" class="auth_mail" title="E-mail the corresponding author ; Xiaohui Puc ; Bingyang Liua ; Zhonggui Hea ; Li Yanga ; pharm305@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Simultaneous determination ; Lovastatin ; Lovastatin acid ; UPLC&ndash ; MS/MS ; Rat plasma ; Pharmacokinetics
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2016
- 出版时间：15 June 2016
- 年：2016
- 卷：1023-1024
- 期：Complete
- 页码：55-61
- 全文大小：998 K
文摘
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Lovastatin and lovastatin acid were determined in rat plasma by UPLC–MS/MS.
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Positive/negative ion-switching function was used to monitor the two analytes.
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The method was proved to be sensitive, selective and rapid.
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It has been successfully applied to pharmacokinetic study of LOV-NS.