Long period fiber grating nano-optrode for cancer biomarker detection
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- 作者：Giuseppe Queroa ; 1 ; Marco Consalesa ; 1 ; Renato Severinoa ; Patrizio Vaianoa ; Alessandra Bonielloa ; Annamaria Sandomenicob ; c ; Menotti Ruvob ; c ; menotti.ruvo@unina.it" class="auth_mail" title="E-mail the corresponding author ; Anna Borriellod ; anna.borriello@cnr.it" class="auth_mail" title="E-mail the corresponding author ; Laura Diodatod ; Simona Zuppolinid ; Michele Giordanod ; Immacolata Cristina Nettoree ; Claudia Mazzarellaf ; Annamaria Colaoe ; Paolo Emidio Macchiae ; Flavio Santorellig ; Antonello Cutoloa ; Andrea Cusanoa ; a.cusano@unisannio.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：Optical fiber biosensor ; Long period fiber grating (LPG) ; Reflection-type LPG ; Human Thyroglobulin (TG) detection ; Biomolecular sensing ; Label-free detection
- 刊名：Biosensors and Bioelectronics
- 出版年：2016
- 出版时间：15 June 2016
- 年：2016
- 卷：80
- 期：Complete
- 页码：590-600
- 全文大小：1192 K
文摘
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A new LPG nano-optrode for Tg detection, a marker of differentiated thyroid cancer.
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A reflection-type LPG working in “transition-mode” as highly sensitive RI transducer.
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The RT-LPG is functionalized with a high affinity anti-Tg monoclonal antibody.
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Analyte capture confirmed for the first time by a parallel on fiber ELISA-like assay.
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Linear biosensor response between 0-4 ng/mL; saturation occurs for higher Tg levels.