Glial cross-talk by transmembrane chemokines CX3CL1 and CXCL16

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• 作者：Andreas Ludwig ; Rolf Mentlein
• 关键词：Astroglia ; Glial precursor cells ; Chemokines ; Metalloproteinases ; Shedding ; Chemotaxis ; Proliferation ; Neuroinflammation ; Glioma
• 刊名：Journal of Neuroimmunology
• 出版年：2008
• 出版时间：31 July 2008
• 年：2008
• 卷：198
• 期：1-2
• 页码：92-97
• 全文大小：341 K

文摘

The transmembrane chemokines CX3CL1 and CXCL16 mediate chemotaxis and cell to cell adhesion by interaction with their receptors CXCR6 and CX3CR1, respectively. We here summarize reports on the expression, regulation and proteolytic processing of transmembrane chemokines by glial cells, their activity on glial cells/glial precursor cells and their role in glial cell cross-talk under physiological and pathophysiological conditions.