The effect of high-frequency oscillatory ventilation combined with tracheal gas insufflation on extravascular lung water in patients with acute respiratory distress syndrome: A randomized, crossover, physiologic study

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• 作者：Charikleia S. Vrettou ; MD ; MRCP ; ^{vrettou@hotmail.com" class="auth_mail} ; Spyros G. Zakynthinos ; MD ; PhD ; Sotirios Malachias ; MD ; Spyros D. Mentzelopoulos ; MD ; PhD
• 关键词：Acute respiratory distress syndrome ; Extravascular lung water ; High-frequency ventilation
• 刊名：Journal of Critical Care
• 出版年：August 2014
• 年：2014
• 卷：29
• 期：4
• 页码：568-573
• 全文大小：354 K

文摘

High-frequency oscillation combined with tracheal gas insufflation (HFO-TGI) improves oxygenation in patients with acute respiratory distress syndrome (ARDS). There are limited physiologic data regarding the effects of HFO-TGI on hemodynamics and pulmonary edema during ARDS. The aim of this study was to investigate the effect of HFO-TGI on extravascular lung water (EVLW).

d="absSec_2">Materials and methods

d="sp0010">We conducted a prospective, randomized, crossover study. Consecutive eligible patients with ARDS received sessions of conventional mechanical ventilation with recruitment maneuvers (RMs), followed by HFO-TGI with RMs, or vice versa. Each ventilatory technique was administered for 8 hours. The order of administration was randomly assigned. Arterial/central venous blood gas analysis and measurement of hemodynamic parameters and EVLW were performed at baseline and after each 8-hour period using the single-indicator thermodilution technique.

d="absSec_3">Results

d="sp0015">Twelve patients received 32 sessions. Pao₂/fraction of inspired oxygen and respiratory system compliance were higher (P < .001 for both), whereas extravascular lung water index to predicted body weight and oxygenation index were lower (P = .021 and .029, respectively) in HFO-TGI compared with conventional mechanical ventilation. There was a significant correlation between Pao₂/fraction of inspired oxygen improvement and extravascular lung water index drop during HFO-TGI (Rs = − 0.452, P = .009).

d="absSec_4">Conclusions

d="sp0020">High-frequency oscillation combined with tracheal gas insufflation improves gas exchange and lung mechanics in ARDS and potentially attenuates EVLW accumulation.