Effects of older age and age of asthma onset on clinical and inflammatory variables in severe refractory asthma
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- 作者：Rekha Chaudhuria ; b ; rekhachaudhuri@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Charles McSharrya ; b ; Liam G. Heaneyc ; Robert Nivend ; e ; Christopher E. Brightlingf ; Andrew N. Menzies-Gowg ; Christine Bucknallh ; Adel H. Mansuri ; Waiting Leea ; b ; Malcolm Shepherda ; b ; Mark Spearsa ; b ; Douglas C. Cowana ; b ; Holger Husij ; Neil C. Thomsona ; b ; on behalf of the BTS Severe Asthma Network
- 关键词：Asthma ; Adult-onset ; Asthma duration ; Childhood-onset ; Elderly ; Inflammatory biomarker
- 刊名：Respiratory Medicine
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：118
- 期：Complete
- 页码：46-52
- 全文大小：255 K
文摘
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Older people with severe asthma have better clinical outcomes than those <65 years.
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Severe asthma in older people is also associated with lower blood eosinophils.
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Clinical outcomes are similar in early-onset and adult-onset severe asthma.
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Severe adult-onset asthma is associated with high blood eosinophils and less atopy.