Identification of a Nuclear Exosome Decay Pathway for Processed Transcripts
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- 作者：Nicola Meola1 ; 4 ; Michal Domanski1 ; 4 ; 5 ; Evdoxia Karadoulama1 ; 2 ; Yun Chen2 ; Coline Gentil1 ; Dennis Pultz3 ; Kristoffer Vitting-Seerup2 ; Sø ; ren Lykke-Andersen1 ; Jens S. Andersen3 ; Albin Sandelin2 ; Torben Heick Jensen1 ; 6 ; thj@mbg.au.dk" class="auth_mail" title="E-mail the corresponding author
- 关键词：nuclear RNA decay ; RNA exosome ; NEXT complex ; PAXT connection ; poly(A) tail
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：3 November 2016
- 年：2016
- 卷：64
- 期：3
- 页码：520-533
- 全文大小：5016 K
文摘
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ZFC3H1 links MTR4 with PABPN1 in the poly(A) tail exosome targeting (PAXT) connection
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ZFC3H1 and RBM7/ZCCHC8 (NEXT) interact with MTR4 in a mutually exclusive manner
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PAXT and NEXT direct distinct RNA species for nuclear exosome degradation
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PAXT targets tend to be longer and more extensively polyadenylated than NEXT targets