Functional regulation of PI3K-associated signaling in the accumbens by binge alcohol drinking in male but not female mice
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- 作者：Debra K. Cozzolia ; Moriah N. Kaufmana ; Michelle A. Nippera ; Joel G. Hashimotoa ; Kristine M. Wirena ; b ; Deborah A. Finna ; b ; finnd@ohsu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Group 1 metabotropic glutamate receptor ; Homer2 ; Rapamycin ; SHAC procedure ; Sex differences ; Nucleus accumbens
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：105
- 期：Complete
- 页码：164-174
- 全文大小：1639 K
文摘
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Binge drinking recruits sexually divergent signaling cascades in the accumbens.
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Intra-accumbens rapamycin decreases binge drinking only in male mice.
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Binge drinking decreased PI3K signaling in the accumbens only in male mice.
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Age did not alter sex differences in accumbens signaling after binge drinking.