Poly (I:C)-DOTAP cationic nanoliposome containing multi-epitope HER2-derived peptide promotes vaccine-elicited anti-tumor immunity in a murine model
详细信息 查看全文
- 作者：Ghazal Alipour Talesha ; 1 ; ghazal.alipour@sydney.edu.au" class="auth_mail" title="E-mail the corresponding author ; Zahra Ebrahimia ; Ali Badieea ; Badieea@mums.ac.ir" class="auth_mail" title="E-mail the corresponding author ; Mercedeh Mansouriana ; Hossein Attarb ; Leila Arabia ; Seyed Amir Jalalia ; c ; JalaliA@sbmu.ac.ir" class="auth_mail" title="E-mail the corresponding author ; Mahmoud Reza Jaafaria ; d ; Jafarimr@mums.ac.ir" class="auth_mail" title="E-mail the corresponding author ; jaafari42@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Breast cancer vaccine ; HER2/neu peptide immunotherapy ; Poly (I ; C) ; Cationic liposome ; Peptide vaccine
- 刊名：Immunology Letters
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：176
- 期：Complete
- 页码：57-64
- 全文大小：1279 K
文摘
- •
Cancer vaccines are a promising tool to control tumor progression.
- •
When administrated alone, peptide based vaccines are poorly immunogenic.
- •
We developed a vaccine adjuvant system to enhance antitumor immunity against HER2.
- •
We optimized a system composed of Poly (I:C), DOTAP and HER2 derived P5 peptide.
- •
DOTAP-CHOL-P5-Poly (I:C) induced strong antitumor responses in vitro and in vivo.