Hot spot mutations in Finnish non-small cell lung cancers
详细信息 查看全文
- 作者：Satu Mä ; ki-Nevalaa ; satu.maki-nevala@helsinki.fi" class="auth_mail" title="E-mail the corresponding author ; Virinder Kaur Sarhadia ; virinder.sarhadi@helsinki.fi" class="auth_mail" title="E-mail the corresponding author ; Mikko Rö ; ntyb ; 1 ; mikko.ronty@helsinki.fi" class="auth_mail" title="E-mail the corresponding author ; Eeva Kettunenc ; eeva.kettunen@ttl.fi" class="auth_mail" title="E-mail the corresponding author ; Kirsti Husgafvel-Pursiainenc ; kirsti.husgafvel-pursiainen@ttl.fi" class="auth_mail" title="E-mail the corresponding author ; Henrik Wolffc ; henrik.wolff@ttl.fi" class="auth_mail" title="E-mail the corresponding author ; Aija Knuuttilad ; aija.knuuttila@hus.fi" class="auth_mail" title="E-mail the corresponding author ; Sakari Knuutilaa ; sakari.knuutila@helsinki.fi" class="auth_mail" title="E-mail the corresponding author
- 关键词：Lung cancer ; Non-small cell lung cancer ; Mutation
- 刊名：Lung Cancer
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：99
- 期：Complete
- 页码：102-110
- 全文大小：1078 K
文摘
- •
Frequency of known mutations in Finnish NSCLC is similar to Western patients.
- •
KRAS codon 12 mutations are the most common recurrent mutations.
- •
Frequency of BRAF mutations is higher in Finnish NSCLC, although lower for V600E.
- •
STK11 and ERBB2 mutations have lower frequencies in Finnish NSCLC patients.
- •
TP53 mutations occurred often with other mutations (PIK3CA, EGFR, BRAF, MET, KRAS).