Identifying sensitive windows for prenatal particulate air pollution exposure and mitochondrial DNA content in cord blood

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• 作者：Maria José ; Rosa ; PH^a ; ^{maria.rosa@mssm.edu} (Dr) ; Allan C. Just ; PhD^a ; ^{allan.just@mssm.edu} ; Marco Sá ; nchez Guerra ; PhD^b ; ^{m.sanchezguerra@inper.gob.mx} ; Itai Kloog ; PhD^c ; ^{ikloog@bgu.ac.il} ; Hsiao-Hsien Leon Hsu ; ScD^a ; ^{leon.hsu@mssm.edu} ; Kasey J. Brennan^d ; ^{kb2891@cumc.columbia.edu} ; Adriana Mercado Garcí ; a ; MD^e ; ^{adrianam@insp.mx} ; Brent Coull ; PhD^f ; ^{bcoull@hsph.harvard.edu} ; Rosalind J. Wright ; MD MPH^g ; ^h ; ^{rosalind.wright@mssm.edu} ; Martha Marí ; a Té ; llez Rojo ; PhD^e ; ^{mmtellez@insp.mx} ; Andrea A. Baccarelli ; MD PhD MPH^d ; ^{andrea.baccarelli@cumc.columbia.edu} ; Robert O. Wright ; MD MPH^a ; ^h ; ^{robert.wright@mssm.edu}
• 关键词：DLM ; distributive lag models ; mitochondrial DNA ; mtDNA ; PM2.5 ; particulate matter < ;   ; 2.5  ; μm in diameter ; qPCR ; quantitative real time polymerase chain reaction ; ROS ; reactive oxygen species
• 刊名：Environment International
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：98
• 期：Complete
• 页码：198-203
• 全文大小：470 K
• 卷排序：98

文摘

Examined sensitive windows of prenatal PM2.5 exposure on mtDNA in cord blood Sensitive window identified at gestational weeks 35–40 Higher PM2.5 during sensitive window associated with lower mtDNA content Findings suggest sex-specific associations.