Donepezil聽+聽propargylamine聽+聽8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease
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- 作者：Li Wanga ; 1 ; Gerard Estebanb ; 1 ; Masaki Ojimaa ; Oscar M. Bautista-Aguilerac ; Tsutomu Inokuchia ; ; Ignacio Moraledad ; Isabel Iriepad ; Abdelouahid Samadic ; Moussa B.H. Youdime ; Alejandro Romerof ; Elena Sorianog ; Raquel Herreroh ; Ana Patricia Ferná ; ndez Ferná ; ndezh ; Ricardo-Martí ; nez-Murilloh ; José ; Marco-Contellesc ; ; Mercedes Unzetab ; Mercedes.Unzeta@uab.cat" class="auth_mail ; mercedes.unzeta@uab.es" class="auth_mail
- 关键词：Donepezil + Propargylamine + 8-Hydroxyquinoline hybrids ; Multifunctional drugs ; Fe/Cu/Zn chelators ; ChE and MAO inhibitors ; In vivo scopolamine-induced long-term memory deficit ; Alzheimer's disease
- 刊名：European Journal of Medicinal Chemistry
- 出版年：10 June 2014
- 年：2014
- 卷：80
- 期：Complete
- 页码：543-561
- 全文大小：3033 K
文摘
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New multipotent MAO + ChE inhibitors.
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Donepezil + Propargyl + 8-Hydroxyquinoline hybrids for Alzheimer's disease.
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DPH6 is a moderate rMAO A/B, EeAChE and eqBuChE inhibitor.
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DPH6 is an irreversible MAO A/B inhibitor.
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DPH6 decreases scopolamine-induced learning deficits in healthy adult mice.