Juvenile exposure to a high fat diet promotes behavioral and limbic alterations in the absence of obesity
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- 作者：Angeles Vinuesaa ; b ; Carlos Pomilioa ; b ; Martin Menafrac ; Maria Marta Bonaventurab ; Laura Garayb ; Marí ; a Florencia Mercoglianob ; Roxana Schillacib ; Victoria Lux Lantosb ; Fernando Britesc ; Juan Beauquisa ; b ; Flavia Saraviaa ; b ; fsaravia@qb.fcen.uba.ar" class="auth_mail" title="E-mail the corresponding author ; fesaravia@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：AD ; Alzheimer&rsquo ; s disease ; CD ; control diet ; DCX ; doublecortin ; DG ; dentate gyrus ; EPM ; elevated plus maze ; GCL ; granular cell layer ; HFD ; high fat diet ; HPA ; hypothalamic-pituitary-adrenal axis ; Iba1 ; ionized calcium binding adapter molecule 1 ; IL1β ; interleuquin 1 β ; IRS ; insulin receptor substrate ; Lp-PLA2 ; Lipoprotein-associated phospholipase A2 ; NB ; nest building ; NOL ; novel object location recognition test ; SGZ ; subgranular zone ; T2D ; type 2 diabetes ; TNFα ; tumor necrosis factor α ; TST
- 刊名：Psychoneuroendocrinology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：72
- 期：Complete
- 页码：22-33
- 全文大小：2475 K
文摘
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Mice fed with high fat diet (HFD) developed hyperinsulinemia, dyslipidemia and prothrombotic risk.
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The liver of HDF mice showed high inflammatory mediators, lipid content and impaired insulin signaling.
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HFD during early life was linked to cognitive impairment, anxiety and depressive symptoms in adulthood.
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HFD induced microglial activation, defective neurogenesis and insulin signaling in the hippocampus.
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Juvenile mice exposed to HFD manifested perturbed emotionality together with amygdala compromise.