Influence of MTHFR polymorphisms on cardiovascular risk markers in elite athletes
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- 作者：Monica Currò ; 1 ; monica.curro@unime.it" class="auth_mail" title="E-mail the corresponding author ; Debora Di Mauro1 ; ddimauro@unime.it" class="auth_mail" title="E-mail the corresponding author ; Daniele Bruschetta daniele.bruschetta@unime.it" class="auth_mail" title="E-mail the corresponding author ; Federico D'Amico fededamico92@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Mercurio Vecchio mercuriovecchio@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Fabio Trimarchi fatrim@unime.it" class="auth_mail" title="E-mail the corresponding author ; Riccardo Ientile ; ientile@unime.it" class="auth_mail" title="E-mail the corresponding author ; Daniela Caccamo dcaccamo@unime.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：Elite athletes ; Cardiovascular risk ; Homocysteine ; Advanced oxidation protein products ; Gene polymorphisms
- 刊名：Clinical Biochemistry
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：49
- 期：1-2
- 页码：183-185
- 全文大小：217 K
文摘
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MTHFR and PON1 polymorphisms modulate plasma levels of homocysteine and oxidated proteins, respectively.
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The highest Hcy plasma levels, together with the lowest folates, were observed in MTHFR TT677/AA1298 subjects in both groups.
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Growing AOPP plasma concentrations were observed in hurdlers with either MTHFR CT677/AC1298 or TT677/AA1298 diplotypes.
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AOPP were positively correlated with Hcy, and both markers were positively dependent on MTHFR genotype in hurdlers.