The Classical Lancefield Antigen of Group A Streptococcus Is a Virulence Determinant with Implications for Vaccine Design
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- 作者：Nina M. van Sorge1 ; 6 ; 15 ; n.vansorge-3@umcutrecht.nl" class="auth_mail ; Jason N. Cole1 ; 7 ; 15 ; Kirsten Kuipers1 ; Anna Henningham1 ; 7 ; Ramy K. Aziz2 ; 8 ; Ana Kasirer-Friede3 ; Leo Lin1 ; Evelien T.M. Berends6 ; Mark R. Davies7 ; 9 ; Gordon Dougan9 ; Fan Zhang10 ; Samira Dahesh1 ; Laura Shaw1 ; Jennifer Gin4 ; Madeleine Cunningham11 ; Joseph A. Merriman12 ; Julia Hü ; tter13 ; 14 ; Bernd Lepenies13 ; 14 ; Suzan H.M. Rooijakkers6 ; Richard Malley10 ; Mark J. Walker7 ; Sanford J. Shattil3 ; Patrick M. Schlievert12 ; Biswa Choudhury5 ; Victor Nizet1 ; 4 ; 5 ; vnizet@ucsd.edu" class="auth_mail
- 刊名：Cell Host Microbe
- 出版年：11 June 2014
- 年：2014
- 卷：15
- 期：6
- 页码：729-740
- 全文大小：3398 K
文摘
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The genetic locus for the Lancefield group A carbohydrate (GAC) is identified
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The gacI gene is essential for expression of the signature GAC GlcNAc epitope
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The GAC GlcNAc side chain is required for full GAS virulence in animal models
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Antibodies against GlcNAc-deficient GAC protect against streptococcal challenge