MERTK signaling in the retinal pigment epithelium regulates the tyrosine phosphorylation of GDP dissociation inhibitor alpha from the GDI/CHM family of RAB GTPase effectors
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- 作者：Shameka J. Shelbya ; b ; Kecia L. Feathersb ; 1 ; Anna M. Ganiosa ; Lin Jiab ; Jason M. Millerb ; 1 ; Debra A. Thompsona ; b ; dathom@umich.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Phagocytosis ; RAB GTPase ; Retinal dystrophy ; Retinal pigment epithelium ; Tyrosine phosphorylation
- 刊名：Experimental Eye Research
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：140
- 期：Complete
- 页码：28-40
- 全文大小：3175 K
文摘
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The RAB GTPase effector GDI1 is tyrosine phosphorylated coincident with peak phagocytic uptake in the RPE.
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GDI1 colocalizes with MERTK and SRC on phagosomes in the RPE.
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MERTK activation of SRC results in tyrosine phosphorylation of GDI1 and decreased interaction with RAB5.
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MERTK signaling in the RPE is directly linked to mechanisms of membrane remodeling.