Microinjection of the melanin-concentrating hormone into the sublaterodorsal tegmental nucleus inhibits REM sleep in the rat
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- 作者：Jaime M. Montia ; jmonti@mednet.org.uy" class="auth_mail" title="E-mail the corresponding author ; Pablo Torterolob ; Hé ; ctor Jantosa ; Patricia Lagosb
- 关键词：DPGi ; dorsal gigantocellular nucleus ; DPMe ; deep mesencephalic nucleus ; DRN ; dorsal raphe nucleus ; GABA ; γ-aminobutyric acid ; LC ; locus coeruleus ; LS ; light sleep ; MCH ; melanin concentrating hormone ; NPO ; nucleus pontis oralis ; REMS ; rapid-eye-movement sleep ; SLD ; sublaterodorsal tegmental nucleus ; SWS ; slow wave sleep ; vlPAG ; ventrolateral periaqueductal gray ; VLPO ; ventrolateral preoptic area ; W ; wakefulness
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：6 September 2016
- 年：2016
- 卷：630
- 期：Complete
- 页码：66-69
- 全文大小：1312 K
文摘
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Melanin-concentrating hormone has been characterized as a REMS-promoting neurotransmitter.
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The sublaterodorsal nucleus has been proposed to induce and maintain REMS in the rat.
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Unilateral microinjection of melanin-concentrating hormone into the sublaterodorsal nucleus reduced REMS.
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The effect would be related to the direct inhibition of glutamatergic neurons of the sublaterodorsal nucleus.