ZEB1 is neither sufficient nor required for epithelial-mesenchymal transition in LS174T colorectal cancer cells

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• 作者：Sabine Jä ; gle^a ; ¹ ; Annika Dertmann^a ; ¹ ; ² ; Monika Schrempp^a ; Andreas Hecht^a ; ^b ; ^c ; ^{andreas.hecht@mol-med.uni-freiburg.de}
• 关键词：Colorectal cancer ; Epithelial-mesenchymal transition ; Genome editing ; Tumor cell invasion ; SNAIL1 ; ZEB1
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：22 January 2017
• 年：2017
• 卷：482
• 期：4
• 页码：1226-1232
• 全文大小：2160 K
• 卷排序：482

文摘

No repression of epithelial markers in LS174T colon cancer cells by ectopic ZEB1. Oxaliplatin-resistance of LS174T cells not affected by ZEB1 overexpression. Minor effects of overexpressed ZEB1 on morphology and invasive growth of LS174T cells. No impairment of Snail1-induced EMT upon CRISPR/Cas9-mediated knock-out of ZEB1. Differential EMT-inducing capacity of Snail1 and ZEB1 in colorectal cancer cells.