Bleomycin-induced epithelial-mesenchymal transition in sclerotic skin of mice: Possible role of oxidative stress in the pathogenesis
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- 作者：Cheng-Fan Zhoua ; b ; 1 ; zhouchengfan@sohu.com" class="auth_mail ; Deng-Chuan Zhouc ; 1 ; Jia-Xiang Zhangb ; Feng Wangb ; Wan-Sheng Chab ; Chang-Hao Wud ; Qi-Xing Zhua ; b ; zqxing@yeah.net" class="auth_mail
- 关键词：EMT ; Epithelial&ndash ; mesenchymal transition ; BLM ; Bleomycin ; NAC ; N-acetylcysteine ; BMZ ; Basement membrane zone ; ROS ; Reactive oxygen species ; MDA ; Malondialdehyde
- 刊名：Toxicology and Applied Pharmacology
- 出版年：15 June 2014
- 年：2014
- 卷：277
- 期：3
- 页码：250-258
- 全文大小：1924 K
文摘
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We provided the first evidence that EMT occurred in BLM-induced skin fibrosis.
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Epithelial cells superficial to the BMZ underwent EMT in BLM-induced skin fibrosis.
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NAC attenuated EMT induction in the process of BLM-induced skin fibrosis.
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NAC didn't significantly inhibit TGF-尾 expression in BLM-induced skin fibrosis.