MESNA pretreatment reduced ethanol-induced gastric injury in mice.
Gastroprotective effect of MESNA was confirmed by macro and microscopic examination.
MESNA significantly increased the levels of GSH, CAT and SOD in the gastric tissues.
MESNA reduced ethanol-induced lipid peroxidation and MPO activity.
MESNA reduced ethanol-induced TNF-α, IL-1β, IL-6 and MCP-1 levels.