Gastroprotective effect of 2-mercaptoethane sulfonate against acute gastric mucosal damage induced by ethanol
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- 作者：Keyvan Amirshahrokhia ; k.amirshahrokhi@arums.ac.ir" class="auth_mail" title="E-mail the corresponding author ; k.amirshahrokhi@pharmacy.arums.ac.ir" class="auth_mail" title="E-mail the corresponding author ; Ali-Reza Khalilib
- 关键词：MESNA ; Inflammation ; Antioxidant ; Gastric mucosal damage ; Ethanol
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：34
- 期：Complete
- 页码：183-188
- 全文大小：699 K
文摘
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MESNA pretreatment reduced ethanol-induced gastric injury in mice.
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Gastroprotective effect of MESNA was confirmed by macro and microscopic examination.
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MESNA significantly increased the levels of GSH, CAT and SOD in the gastric tissues.
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MESNA reduced ethanol-induced lipid peroxidation and MPO activity.
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MESNA reduced ethanol-induced TNF-α, IL-1β, IL-6 and MCP-1 levels.